Henrich W, Schmider A, Henrich M, Dudenhausen J W
Department of Obstetrics and Gynecology, Charité Campus Virchow-Klinikum, Humboldt-University of Berlin, Germany.
J Perinat Med. 2001;29(2):155-7. doi: 10.1515/JPM.2001.021.
Postthrombotic syndrome is an important late complication after deep vein thrombosis in pregnancy. Thrombolytic agents are more efficient in preventing this condition but are rarely used in pregnant women.
A 22-year-old woman at 29 weeks of gestation presented with acute iliac vein thrombosis. After application of a heparin bolus, systemic streptokinase lysis was performed. Low-dose heparin therapy was continued for the remainder of the, otherwise unremarkable, pregnancy. Spontaneous delivery of a healthy girl was without complications and thromboprophylaxis with low-molecular heparin was continued.
Thrombolysis in pregnancy is possible and may help to prevent severe long-term sequelae of thrombosis in young women. Bleeding is a major risk, which must be considered and therapy should only be administered under close observation.
血栓形成后综合征是妊娠期深静脉血栓形成后的一种重要晚期并发症。溶栓药物在预防这种情况方面更有效，但很少用于孕妇。
一名29孕周的22岁女性出现急性髂静脉血栓形成。给予肝素推注后，进行了全身链激酶溶栓治疗。在其余未出现其他异常情况的孕期继续给予低剂量肝素治疗。顺产一名健康女婴，无并发症，继续给予低分子肝素进行血栓预防。
妊娠期溶栓是可行的，可能有助于预防年轻女性血栓形成的严重长期后遗症。出血是主要风险，必须予以考虑，且治疗应仅在密切观察下进行。
