Clark R E, West A N, Zola S M, Squire L R
Department of Psychiatry, University of California at San Diego, La Jolla, USA.
Hippocampus. 2001;11(2):176-86. doi: 10.1002/hipo.1035.
Rats with ibotenic acid lesions of the hippocampus (H-IBO) were trained on the trial-unique delayed nonmatching-to-sample task (DNMS) using a short delay of 4 s. The H-IBO group learned the nonmatching rule as quickly as control animals. However, performance was impaired on the DNMS task when the delay between the sample and choice phase was increased to 1 or 2 min. The use of 4-s delay (probe) trials indicated that the H-IBO animals retained the nonmatching-to-sample rule throughout testing. In a second experiment, using the same groups of rats, extended training at the 1-min delay did not ameliorate the deficit produced by H-IBO lesions. The finding of impaired recognition memory in rats after hippocampal lesions is consistent with findings from humans and monkeys. Several methodological issues are considered that have complicated the interpretation of earlier studies of recognition memory in rats following hippocampal lesions. The capacity for recognition memory in humans, monkeys, and rodents is discussed as a straightforward example of hippocampus-dependent (declarative) memory.
对海马体注射鹅膏蕈氨酸造成损伤的大鼠（H-IBO）进行了独特试验延迟非匹配样本任务（DNMS）训练，延迟时间设定为4秒。H-IBO组学习非匹配规则的速度与对照动物一样快。然而，当样本阶段和选择阶段之间的延迟增加到1或2分钟时，DNMS任务的表现受到损害。使用4秒延迟（探测）试验表明，H-IBO动物在整个测试过程中都保留了非匹配样本规则。在第二个实验中，使用相同组别的大鼠，在1分钟延迟条件下进行延长训练并没有改善H-IBO损伤所产生的缺陷。海马体损伤后大鼠识别记忆受损这一发现与人类和猴子的研究结果一致。文中考虑了几个方法学问题，这些问题使早期关于海马体损伤后大鼠识别记忆研究的解释变得复杂。人类、猴子和啮齿动物的识别记忆能力被作为海马体依赖（陈述性）记忆的一个直接例子进行了讨论。
