比利时儿童中乙肝病毒基因型和地理来源的多样性
Wide variety of genotypes and geographic origins of hepatitis B virus in Belgian children.
作者信息
Liu H F, Sokal E, Goubau P
机构信息
Unit of Virology, Cliniques Universitaires St Luc Université Catholique de Louvain, Brussels, Belgium.
出版信息
J Pediatr Gastroenterol Nutr. 2001 Mar;32(3):274-7. doi: 10.1097/00005176-200103000-00008.
BACKGROUND
Belgium is a country with low endemicity for hepatitis B virus (HBV) infection. Few data are available on genotypes or serotypes of HBV among infected children.
METHODS
The S region of the hepatitis B virus genome was amplified and sequenced in 23 children treated with interferon-alpha in Belgium. Nucleotide sequences were aligned and compared with other known sequences in a phylogenetic analysis.
RESULTS
A high stability of the S gene was observed during treatment. Four genotypes were represented in this sample of Belgian patients (A, B, D, and E), reflecting the geographic diversity of origins.
CONCLUSIONS
In this series, the wide variety of geographic origins is confirmed by the molecular characteristics of HBV. In Belgium, HBV infection of children is currently essentially an imported infection.
背景
比利时是乙型肝炎病毒（HBV）感染低流行率的国家。关于感染儿童中HBV基因型或血清型的数据很少。
方法
对比利时23名接受α干扰素治疗的儿童的乙肝病毒基因组S区进行扩增和测序。在系统发育分析中，将核苷酸序列进行比对并与其他已知序列进行比较。
结果
治疗期间观察到S基因具有高度稳定性。该比利时患者样本中存在四种基因型（A、B、D和E），反映了来源的地理多样性。
结论
在本系列研究中，HBV的分子特征证实了地理来源的广泛多样性。在比利时，儿童HBV感染目前基本上是输入性感染。
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