Formigari R, Di Donato R M, Mazzera E, Carotti A, Rinelli G, Parisi F, Pasquini L, Ballerini L
Department of Pediatric Cardiac Surgery, Bambino Gesù Hospital, Rome, Italy.
J Am Coll Cardiol. 2001 May;37(6):1707-12. doi: 10.1016/s0735-1097(01)01213-x.
The goal of this study was to evaluate percutaneous interventional and minimally invasive surgical closure of secundum atrial septal defect (ASD) in children.
Concern has surrounded abandoning conventional midline sternotomy in favor of the less invasive approaches pursuing a better cosmetic result and a more rational resource utilization.
A retrospective analysis was performed on the patients treated from June 1996 to December 1998.
One hundred seventy-one children (median age 5.8 years, median weight 22.1 kg) underwent 52 device implants, 72 minimally invasive surgical operations and 50 conventional sternotomy operations. There were no deaths and no residual left to right shunt in any of the groups. The overall complication rate causing delayed discharge was 12.6% for minimally invasive surgery, 12.0% for midline sternotomy and 3.8% for transcatheter device closure (p < 0.01). The mean hospital stay was 2.8 +/- 1.0 days, 6.5 +/- 2.1 days and 2.1 +/- 0.5 days (p < 0.01); the skin-to-skin time was 196 +/- 43 min, 163 +/- 46 min and 118 +/- 58 min, respectively (p < 0.001). Extracorporeal circulation time was 49.9 +/- 10.1 min in the minithoracotomy group versus 37.2 +/- 13.8 min in the sternotomy group (p < 0.01) but without differences in aortic cross-clamping time. Sternotomy was the most expensive procedure (15,000 EUR +/- 1,050 EUR vs. 12,250 EUR +/- 472 EUR for minithoracotomy and 13,000 EUR +/- 300 EUR for percutaneous devices).
While equally effective compared with sternotomy, the cosmetic and financial appeal of the percutaneous and minimally invasive approaches must be weighed against their greater exposure to technical pitfalls. Adequate training is needed if a strategy of surgical or percutaneous minimally invasive closure of ASD in children is planned in place of conventional surgery.
本研究的目的是评估儿童继发孔型房间隔缺损(ASD)的经皮介入和微创外科封堵术。
人们一直关注放弃传统的正中开胸术,转而采用侵入性较小的方法,以获得更好的美容效果和更合理的资源利用。
对1996年6月至1998年12月期间接受治疗的患者进行回顾性分析。
171名儿童(中位年龄5.8岁,中位体重22.1kg)接受了52次器械植入、72次微创外科手术和50次传统开胸手术。所有组均无死亡病例,也无残余左向右分流。导致延迟出院的总体并发症发生率在微创外科手术中为12.6%,在正中开胸手术中为12.0%,在经导管器械封堵术中为3.8%(p<0.01)。平均住院时间分别为2.8±1.0天、6.5±2.1天和2.1±0.5天(p<0.01);皮肤对皮肤时间分别为196±43分钟、163±46分钟和118±58分钟(p<0.001)。微创开胸组体外循环时间为49.9±10.1分钟,开胸组为37.2±13.8分钟(p<0.01),但主动脉阻断时间无差异。开胸手术是最昂贵的手术(15,000欧元±1,050欧元,微创开胸手术为12,250欧元±472欧元,经皮器械为13,000欧元±300欧元)。
虽然与开胸手术同样有效,但经皮和微创方法的美容和经济吸引力必须与其面临更多技术陷阱的情况相权衡。如果计划采用手术或经皮微创封堵儿童ASD的策略来替代传统手术,则需要进行充分的培训。