NMDA拮抗剂CGP 37849与σ受体激动剂SA4503或DTG联合治疗可减轻大鼠的抗精神病药物诱导的僵住症。
Combined treatment with NMDA antagonist, CGP 37849, and sigma receptor agonists, SA4503 or DTG, decreases the neuroleptic-induced catalepsy in rats.
作者信息
Skuza G
机构信息
Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Kraków.
出版信息
Pol J Pharmacol. 2000 Jul-Aug;52(4):313-6.
PMID:11345488
Abstract
The obtained results indicate that joint administration of CGP 37849, a competitive NMDA receptor antagonist, and SA4503, a sigma1 (sigma1) receptor agonist or DTG, sigma 1/2 receptor agonist, evoked anticataleptic effect at doses which were ineffective when each of the compounds was given alone.
摘要
所得结果表明，竞争性N-甲基-D-天冬氨酸（NMDA）受体拮抗剂CGP 37849与σ1受体激动剂SA4503或σ1/2受体激动剂DTG联合给药时，在单独给予每种化合物无效的剂量下可诱发抗僵住效应。
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