PAProC：一种可在万维网上获取的蛋白酶体切割预测算法。

PAProC: a prediction algorithm for proteasomal cleavages available on the WWW.

作者信息

Nussbaum A K, Kuttler C, Hadeler K P, Rammensee H G, Schild H

机构信息

Universität Tübingen, Interfakultäres Institut für Zellbiologie, Abteilung Immunologie, Auf der Morgenstelle 15, 72076 Tübingen, Germany.

出版信息

Immunogenetics. 2001 Mar;53(2):87-94. doi: 10.1007/s002510100300.

DOI:10.1007/s002510100300

PMID:11345595

Abstract

The first version of PAProC (Prediction Algorithm for Proteasomal Cleavages) is now available to the general public. PAProC is a prediction tool for cleavages by human and yeast proteasomes, based on experimental cleavage data. It will be particularly useful for immunologists working on antigen processing and the prediction of major histocompatibility complex class I molecule (MHC I) ligands and cytotoxic T-lymphocyte (CTL) epitopes. Likewise, in cases in which proteasomal protein degradation has been indicated in disease, PAProC can be used to assess the general cleavability of disease-linked proteins. On its web site (http://www.paproc.de), background information and hyperlinks are provided for the user (e.g., to SYFPEITHI, the database for the prediction of MHC I ligands).

摘要

PAProC（蛋白酶体切割预测算法）的首个版本现已向公众开放。PAProC是一种基于实验切割数据的人类和酵母蛋白酶体切割预测工具。它对于从事抗原加工以及预测主要组织相容性复合体I类分子（MHC I）配体和细胞毒性T淋巴细胞（CTL）表位的免疫学家来说将特别有用。同样，在已表明蛋白酶体蛋白降解与疾病相关的情况下，PAProC可用于评估疾病相关蛋白的一般可切割性。在其网站（http://www.paproc.de）上，为用户提供了背景信息和超链接（例如，指向预测MHC I配体的数据库SYFPEITHI）。