Bishop G A, Hostager B S
Department of Microbiology, The University of Iowa, Iowa City 52240, USA.
Arch Immunol Ther Exp (Warsz). 2001;49(2):129-37.
CD40, a member of the growing tumor necrosis factor receptor (TNF-R) family of molecules, functions as a transmembrane signal receptor in both hematopoietic and non-hematopoietic cell types, although its physiological roles are less well understood in the latter. Much has been learned over the past decade about the role of CD40 signaling in various cellular functions. In addition, some of the molecular events which occur subsequent to CD40 engagement have been characterized, although much remains to be understood. This review will summarize the known important biological roles of CD40, and discuss what is currently known about how CD40 signals.
CD40是不断增多的肿瘤坏死因子受体（TNF-R）家族分子中的一员，在造血细胞和非造血细胞类型中均作为跨膜信号受体发挥作用，尽管其在后者中的生理作用尚不太清楚。在过去十年中，人们对CD40信号传导在各种细胞功能中的作用已有很多了解。此外，尽管仍有许多有待了解之处，但在CD40激活后发生的一些分子事件已得到表征。本综述将总结CD40已知的重要生物学作用，并讨论目前对CD40信号传导方式的了解。
