吡咯烷核酸：含2-羟基/氨甲基-4-(胸腺嘧啶-1-基)吡咯烷-N-乙酸的DNA/PNA寡聚物
Pyrrolidine nucleic acids: DNA/PNA oligomers with 2-hydroxy/aminomethyl- 4-(thymin-1-yl)pyrrolidine-N-acetic acid.
作者信息
Kumar V, Pallan P S, Meena M, Ganesh K N
机构信息
Division of Organic Chemistry (Synthesis), National Chemical Laboratory, Pune 411008, India.
出版信息
Org Lett. 2001 May 3;3(9):1269-72. doi: 10.1021/ol0069655.
PMID:11348211
Abstract
Synthesis of pyrrolidine-based chiral positively charged DNA analogues is reported. The synthesis of (2S,4S) and (2R,4R) thymin-1-ylpyrrolidine-N-acetic acid, its site specific incorporation in PNA:DNA chimera and PNA, and the study of their binding properties with complementary DNA/RNA sequences is presented.
摘要
报道了基于吡咯烷的手性带正电荷DNA类似物的合成。介绍了(2S,4S)和(2R,4R)胸腺嘧啶-1-基吡咯烷-N-乙酸的合成、其在肽核酸- DNA嵌合体和肽核酸中的位点特异性掺入，以及它们与互补DNA/RNA序列结合特性的研究。
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