氨乙基脯氨酰（aep）肽核酸：嘌呤/嘧啶混合寡聚物以及肽核酸与DNA双链形成时的结合方向偏好
Aminoethylprolyl (aep) PNA: mixed purine/pyrimidine oligomers and binding orientation preferences for PNA:DNA duplex formation.
作者信息
D'Costa M, Kumar V, Ganesh K N
机构信息
Division of Organic Chemistry (Synthesis), National Chemical Laboratory, Pune 411008, India.
出版信息
Org Lett. 2001 May 3;3(9):1281-4. doi: 10.1021/ol015546k.
PMID:11348214
Abstract
[structure in text] The synthesis of (2S,4S)- and (2R,4S)-aepPNA monomers of adenine, guanine, and cytosine (3-5) and their incorporation at appropriate positions into aegPNA sequence 7 leads to mixed aeg-aep backbone/mixed nucleobase PNAs 8-11. The thermal stabilities of the derived duplexes with DNA are found to be dependent on nucleobase and backbone stereochemistry.
摘要
[文本结构] 腺嘌呤、鸟嘌呤和胞嘧啶的(2S,4S)-和(2R,4S)-aepPNA单体（3 - 5）的合成以及它们在适当位置掺入aegPNA序列7中，产生了混合aeg - aep主链/混合核碱基PNA 8 - 11。发现所得与DNA双链体的热稳定性取决于核碱基和主链立体化学。
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