D'Souza C A, Heitman J
Department of Genetics 322 CARL Bldg, Duke University Medical Center, Research Drive, Durham, NC 27710, USA.
FEMS Microbiol Rev. 2001 May;25(3):349-64. doi: 10.1111/j.1574-6976.2001.tb00582.x.
Two well characterized signal transduction cascades regulating fungal development and virulence are the MAP kinase and cAMP signaling cascades. Here we review the current state of knowledge on cAMP signaling cascades in fungi. While the processes regulated by cAMP signaling in fungi are as diverse as the fungi themselves, the components involved in signal transduction are remarkably conserved. Fungal cAMP signaling cascades are also quite versatile, which is apparent from the differential regulation of similar biological processes. In this review we compare and contrast cAMP signaling pathways that regulate development in the budding yeast Saccharomyces cerevisiae, the fission yeast Schizosaccharomyces pombe, and differentiation and virulence in the human pathogen Cryptococcus neoformans and the plant pathogen Ustilago maydis. We also present examples of interaction between the cAMP and MAP kinase signaling cascades in the regulation of fungal development and virulence.
两条已得到充分表征的调节真菌发育和毒力的信号转导级联途径是丝裂原活化蛋白激酶（MAP）和环磷酸腺苷（cAMP）信号转导级联途径。在此，我们综述了目前关于真菌中cAMP信号转导级联途径的知识现状。虽然真菌中由cAMP信号传导调节的过程与真菌本身一样多样，但参与信号转导的组分却显著保守。真菌的cAMP信号转导级联途径也非常多样，这从相似生物学过程的差异调节中可见一斑。在本综述中，我们比较并对比了调节出芽酵母酿酒酵母、裂殖酵母粟酒裂殖酵母发育以及人类病原体新型隐球菌和植物病原体玉米黑粉菌分化与毒力的cAMP信号通路。我们还列举了在调节真菌发育和毒力过程中cAMP与MAP激酶信号转导级联途径之间相互作用的实例。
