慢性实验性血吸虫病期间VβT细胞受体的差异使用与不同的病理表现相对应。
Differential Vbeta T-cell receptor usage during chronic experimental schistosomiasis corresponds with distinct pathological presentations.
作者信息
Secor W E, Freeman G L
机构信息
Immunology Branch, Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, U.S. Department of Health and Human Services, Atlanta, Georgia 30341-3724, USA.
出版信息
Infect Immun. 2001 Jun;69(6):4177-9. doi: 10.1128/IAI.69.6.4177-4179.2001.
Abstract
CBA/J male mice with chronic Schistosoma mansoni infections display either moderate splenomegaly syndrome (MSS) or hypersplenomegaly syndrome (HSS). As MSS and HSS mice differ in several immunologic characteristics, we investigated T-cell receptor Vbeta usage. The groups had significantly different expression of several Vbetas, suggesting a relationship between the T-cell repertoire and schistosomiasis pathology.
摘要
患有慢性曼氏血吸虫感染的CBA/J雄性小鼠表现出中度脾肿大综合征（MSS）或脾肿大综合征（HSS）。由于MSS和HSS小鼠在几个免疫学特征上存在差异，我们研究了T细胞受体Vβ的使用情况。两组在几种Vβ的表达上有显著差异，这表明T细胞库与血吸虫病病理学之间存在关联。
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Neonatal idiotypic exposure alters subsequent cytokine, pathology, and survival patterns in experimental Schistosoma mansoni infections.
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Immunoregulatory idiotypes stimulate T helper 1 cytokine responses in experimental Schistosoma mansoni infections.
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