曼氏血吸虫免疫反应期间CD4 + T细胞受体Vβ的使用情况。
CD4+ T-cell receptor V beta usage during the immune response to Schistosoma mansoni.
作者信息
Vella A T, Pearce E J
机构信息
Department of Microbiology, Immunology and Parasitology, New York State College of Veterinary Medicine, Cornell University, Ithaca 14853-6401.
出版信息
Infect Immun. 1993 Dec;61(12):5381-3. doi: 10.1128/iai.61.12.5381-5383.1993.
Abstract
T-cell receptor V beta usage by CD4+ cells during the immune response of C57BL/6J mice to Schistosoma mansoni was examined. During acute infection, the distribution of splenic CD4+ cells utilizing V beta s 3, 5, 6, 7, 8.1/8.2, 9, and 11 was not significantly different from that in uninfected mice. Preferential V beta usage or deletion was not detected when either the primary or the memory immune response to parasite eggs was examined.
摘要
研究了C57BL/6J小鼠对曼氏血吸虫免疫应答过程中CD4+细胞的T细胞受体Vβ使用情况。在急性感染期间，利用Vβ3、5、6、7、8.1/8.2、9和11的脾CD4+细胞分布与未感染小鼠无显著差异。在检测对寄生虫卵的初次或记忆免疫应答时，未检测到Vβ的优先使用或缺失。
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