用干扰素处理过的各种细胞对聚（rI）·聚（rC）处理的毒性作用的敏感性。
Susceptibility of various cells treated with interferon to the toxic effect of poly(rI).poly(rC) treatment.
作者信息
Emeny J M, Morgan M J
出版信息
J Gen Virol. 1979 Apr;43(1):253-5. doi: 10.1099/0022-1317-43-1-253.
PMID:113495
Abstract
Various cells were treated with interferon and then exposed to polyriboinosinic-polyribocytidylic acid complex [poly(rI).poly(rC)]. With mouse L cells, there was a marked cytotoxic effect from low doses of interferon and poly(rI.poly(rC), whereas chick embryo cells showed an effect only after high doses. When primate cells (LLC.Mk2,BSC.B, Vero and human embryo cells) were treated with human or monkey interferon, poly(rI).poly(rC) was not cytotoxic.
摘要
用干扰素处理各种细胞，然后将其暴露于聚肌苷酸-聚胞苷酸复合物[聚（rI）·聚（rC）]。对于小鼠L细胞，低剂量的干扰素和聚（rI）·聚（rC）会产生明显的细胞毒性作用，而鸡胚细胞仅在高剂量后才显示出作用。当用人类或猴干扰素处理灵长类细胞（LLC.Mk2、BSC.B、Vero和人类胚胎细胞）时，聚（rI）·聚（rC）没有细胞毒性。
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