Yu C P, Hsieh T H, Oller A R, Oberdörster G
Department of Mechanical and Aerospace Engineering, State University of New York at Buffalo, Amherst, NY 14260, USA.
Regul Toxicol Pharmacol. 2001 Apr;33(2):165-72. doi: 10.1006/rtph.2000.1457.
A previously developed dosimetry model of inhaled Ni compounds in the human lung has been expanded by incorporating three additional factors: (1) inhalability, (2) mixed breathing mode, and (3) clearance rate coefficient of a Ni compounds' mixture. Predicted lung burdens of Ni compounds from the expanded model for workers at different departments in a Ni refinery plant compared favorably with the reported data. Although many uncertainties remain, the present model represents a first step toward developing a more meaningful risk assessment tool that will allow for more accurate extrapolation of animal data to humans.
（1）可吸入性，（2）混合呼吸模式，以及（3）镍化合物混合物的清除率系数。镍精炼厂不同部门工人的扩展模型预测的镍化合物肺部负荷与报告数据相比良好。尽管仍存在许多不确定性，但当前模型是朝着开发更有意义的风险评估工具迈出的第一步，该工具将允许更准确地将动物数据外推至人类。
