Brenner C A, McDowell J E, Cadenhead K S, Clementz B A
Department of Psychology, Indiana University, Bloomington, USA.
Psychophysiology. 2001 May;38(3):399-403.
Schizotypal personality disorder (SPD) is theoretically part of the schizophrenia spectrum both clinically and neurobiologically. A liability for developing schizophrenia may be associated with dysfunction of dorsolateral prefrontal cortex (DLPFC) and its cortical and/or subcortical circuitry. If so, abnormalities on tasks associated with DLPFC functioning among SPD subjects would support the thesis that SPD is neurobiologically related to schizophrenia. Antisaccade and ocular motor delayed response performance, both of which are ostensibly supported by DLPFC circuitry, were assessed among 29 SPD, 17 schizophrenia, and 25 normal subjects. Generally, the SPD subjects' performance was more similar to normal than to schizophrenia groups. There was evidence, however, for inhibition abnormalities in a subgroup of SPD subjects. Antisaccade performance identified more SPD subjects as "abnormal" than delayed response measures.
分裂型人格障碍（SPD）在理论上无论是在临床还是神经生物学方面都是精神分裂症谱系的一部分。患精神分裂症的易感性可能与背外侧前额叶皮质（DLPFC）及其皮质和/或皮质下神经回路功能障碍有关。如果是这样，SPD患者中与DLPFC功能相关任务的异常将支持SPD在神经生物学上与精神分裂症相关的论点。对29名SPD患者、17名精神分裂症患者和25名正常受试者进行了反扫视和眼动延迟反应表现评估，这两种表现表面上均由DLPFC神经回路支持。总体而言，SPD患者的表现与正常组比与精神分裂症组更相似。然而，有证据表明一部分SPD患者存在抑制异常。与延迟反应测量相比，反扫视表现将更多的SPD患者识别为“异常”。
