一项关于儿茶酚胺对恒河猴子宫胎盘血流影响的放射血管造影研究。

A radioangiographic study of the effects of catecholamines on uteroplacental blood flow in the rhesus monkey.

作者信息

Wallenburg H C, Hutchinson D L

出版信息

J Med Primatol. 1979;8(1):57-65. doi: 10.1159/000460176.

Abstract

Two placental radioangiographies were performed with a 20-min interval in ten lightly anesthetized rhesus monkeys. Amniotic and aortic pressures, as well as the maternal ECG, were continuously monitored. Norepinephrine or metaproterenol was administered in a low dose which did not cause general cardiovascular effects, prior to the second angiography. Norepinephrine appeared to cause constriction and metaproterenol, dilatation of the uteroplacental vessels. These effects could be diminished or abolished by an alpha- or beta-adrenergic blocking agent, respectively, and thus would appear to be caused by stimulation of adrenergic receptors in the uteroplacental vasculature.

摘要

对十只轻度麻醉的恒河猴进行了两次胎盘放射血管造影，间隔20分钟。持续监测羊水和主动脉压力以及母体心电图。在第二次血管造影前，以低剂量给予去甲肾上腺素或间羟异丙肾上腺素，该剂量不会引起全身心血管效应。去甲肾上腺素似乎导致子宫胎盘血管收缩，间羟异丙肾上腺素则导致其扩张。这些效应可分别被α-或β-肾上腺素能阻滞剂减弱或消除，因此似乎是由子宫胎盘血管系统中肾上腺素能受体的刺激引起的。