Egund N, Carter A M
Acta Radiol Diagn (Stockh). 1980;21(3):389-96.
The effects on uterine and maternal placental circulation of adrenergic and cholinergic drugs, injected selectively in the ovarian and uterine arteries of guinea pigs, were analysed by serial angiography. Noradrenaline, 0.5 nmol/kg, was found to cause a reduction in both ovarian and uterine blood flow, associated with arterial vasoconstriction and impairment of the placental circulation. This response could be prevented by alpha-adrenergic blockade with 25 nmol/kg phenoxybenzamine. At injection into the ovarian artery, phenoxybenzamine alone increased ovarian blood flow and elicited arterial vasodilatation. At injection into the uterine artery the response was more variable, but vasodilatation was observed in four animals of six. Acetylcholine, 0.5 to 5.0 nmol/kg, evoked an increase in both ovarian and uterine blood flow and arterial vasodilatation. When the dose was increased to 50 nmol/kg, dilatation of the extrinsic uterine arteries was maintained, but the placental circulation was reduced due to concomitant contraction of the myometrium. All the effects of acetylcholine could be blocked by prior administration of 10 nmol/kg atropine. This dose of atropine did not affect uterine or placental circulation when given alone.
通过连续血管造影分析了选择性注射到豚鼠卵巢动脉和子宫动脉中的肾上腺素能药物和胆碱能药物对子宫及母体胎盘循环的影响。发现0.5 nmol/kg的去甲肾上腺素会导致卵巢和子宫血流减少，伴有动脉血管收缩和胎盘循环受损。用25 nmol/kg的酚苄明进行α-肾上腺素能阻滞可预防这种反应。单独向卵巢动脉注射酚苄明时，会增加卵巢血流并引起动脉血管舒张。向子宫动脉注射时，反应更具变异性，但在六只动物中有四只观察到血管舒张。0.5至5.0 nmol/kg的乙酰胆碱会引起卵巢和子宫血流增加以及动脉血管舒张。当剂量增加到50 nmol/kg时，子宫外动脉的舒张得以维持，但由于子宫肌层同时收缩，胎盘循环减少。预先给予10 nmol/kg阿托品可阻断乙酰胆碱的所有作用。单独给予该剂量的阿托品时，不会影响子宫或胎盘循环。
