Marks S
Monash Medical Centre, Melbourne, Victoria.
Aust Fam Physician. 2001 Apr;30(4):335-8.
Most antiobesity drugs act centrally to reduce appetite or increase satiety. Orlistat is the first in a new class of drugs targeted at a single dietary component, in this case dietary fat.
To review the clinical actions and efficacy of orlistat and to discuss its place in overall weight management.
Orlistat is best used in long term weight management as an adjunct to dietary modification and increased physical activity. The reduction in fat absorption results in a slow but sustained weight reduction and improved metabolic parameters such as reduced total, and LDL cholesterol. Side effects are minimised by maintaining a low fat diet.
大多数抗肥胖药物通过作用于中枢来降低食欲或增加饱腹感。奥利司他是一类针对单一饮食成分（即膳食脂肪）的新型药物中的首个药物。
综述奥利司他的临床作用和疗效，并讨论其在总体体重管理中的地位。
奥利司他最适合作为饮食调整和增加体育活动的辅助手段用于长期体重管理。脂肪吸收的减少导致体重缓慢但持续下降，并改善代谢参数，如总胆固醇和低密度脂蛋白胆固醇降低。通过维持低脂饮食可将副作用降至最低。
