A retro-inverso Prosaptide D5 promotes a myelination process in developing rats.

作者信息

Hiraiwa M, Campana W M, Wang C Y, Otero D A, O'Brien J S

机构信息

Department of Neurosciences, University of California at San Diego, School of Medicine, Center for Molecular Genetics, La Jolla, CA 92093-0634, USA.

出版信息

Brain Res Dev Brain Res. 2001 May 31;128(1):73-6. doi: 10.1016/s0165-3806(01)00141-9.

The myelinotrophic action of Prosaptide D5 was investigated in developing rats. Sulfatide concentrations in brain and sciatic nerve were determined to assess the development of myelination. Subcutaneous D5-injection significantly increased sulfatide concentrations in both brain and sciatic nerve by 250 and 150% over controls, respectively. D5 promoted ERK phosphorylation in iSC Schwann cells similar to prosaposin. The results showed that D5 treatment stimulated a myelination process in developing rat.