Lenné M, Lintzeris N, Breen C, Harris S, Hawken L, Mattick R, Ritter A
Turning Point Alcohol & Drug Centre Inc, Victoria.
Aust N Z J Public Health. 2001 Apr;25(2):121-5. doi: 10.1111/j.1753-6405.2001.tb01832.x.
To determine the proportion of clients engaged in methadone maintenance treatment who have favourable prognosis for withdrawal, and to examine client perceptions and expectations of withdrawal.
A broad cross-section of 856 methadone clients was sampled across Melbourne, Sydney and Brisbane. Self-complete surveys were developed for the clients, their clinic staff or pharmacists, and methadone prescribers. The client survey examined aspects of the clients' perspectives of withdrawal, and the surveys for the service providers collected information about each client's current treatment episode. Informed consent was provided by clients to obtain information from their clinic staff member or pharmacist, and their methadone prescriber.
Most clients (70%) were at least very interested in methadone withdrawal. Clients were also more optimistic about their own post-withdrawal outcomes (in terms of opioid use) than both their clinic staff and prescribing doctors. Clinical criteria indicated that 31% of clients had a reasonable prognosis for withdrawal. However, when considering all factors, 17% had good withdrawal prognosis, were interested in methadone withdrawal, and believed it was very likely they would remain opioid-free for three months post-withdrawal.
Despite the likely continued increase in client numbers in substitution maintenance treatment, the majority of methadone clients have a poor prognosis for withdrawal and should not be encouraged to cease treatment.
Clients who do not meet key clinical criteria are likely to have poor clinical outcomes regardless of how withdrawal is attempted.
确定接受美沙酮维持治疗且戒断预后良好的患者比例,并考察患者对戒断的认知和期望。
在墨尔本、悉尼和布里斯班对856名美沙酮患者进行广泛抽样。为患者、其诊所工作人员或药剂师以及美沙酮开方者设计了自填式调查问卷。患者调查问卷考察了患者对戒断的看法,服务提供者调查问卷收集了每位患者当前治疗阶段的信息。患者提供了知情同意书,以便从其诊所工作人员或药剂师以及美沙酮开方者处获取信息。
大多数患者(70%)至少对美沙酮戒断非常感兴趣。患者对自己戒断后的结果(就阿片类药物使用而言)也比其诊所工作人员和开方医生更为乐观。临床标准表明,31%的患者戒断预后合理。然而,综合考虑所有因素后,17%的患者戒断预后良好,对美沙酮戒断感兴趣,并且认为他们很有可能在戒断后三个月内保持无阿片类药物状态。
尽管替代维持治疗的患者数量可能会持续增加,但大多数美沙酮患者戒断预后不佳,不应鼓励他们停止治疗。
不符合关键临床标准的患者,无论尝试何种戒断方式,临床结局可能都较差。