帕金森病与α-突触核蛋白/载脂蛋白E联合易感性基因型无关。
Parkinson's disease is not associated with the combined alpha-synuclein/apolipoprotein E susceptibility genotype.
作者信息
Khan N, Graham E, Dixon P, Morris C, Mander A, Clayton D, Vaughan J, Quinn N, Lees A, Daniel S, Wood N, de Silva R
机构信息
Neurogenetics Section, Institute of Neurology, London, UK.
出版信息
Ann Neurol. 2001 May;49(5):665-8.
A recent study showed significant association of sporadic Parkinson's disease with a polymorphism within the alpha-synuclein gene and closely linked DNA markers on chromosome 4q and the APOE epsilon4 allele. A combined alpha-synuclein/APOE-epsilon4 genotype increased the relative risk of developing Parkinson's disease 12-fold. We failed to confirm this association in a much larger sample of histopathologically proven cases of Parkinson's disease and controls.
最近一项研究表明，散发性帕金森病与α-突触核蛋白基因内的一种多态性、4号染色体上紧密连锁的DNA标记以及APOE ε4等位基因之间存在显著关联。α-突触核蛋白/APOE-ε4联合基因型使患帕金森病的相对风险增加了12倍。在一个更大的经组织病理学证实的帕金森病病例和对照样本中，我们未能证实这种关联。
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