一种将碳酸酐酶与氯/碳酸氢根阴离子交换体连接起来的膜代谢体。
A membrane metabolon linking carbonic anhydrase with chloride/bicarbonate anion exchangers.
作者信息
Reithmeier R A
机构信息
Department of Medicine, Room 7344, CIHR Group in Membrane Biology, Medical Sciences Building, Toronto, M5S 1A8, Canada.
出版信息
Blood Cells Mol Dis. 2001 Jan-Feb;27(1):85-9. doi: 10.1006/bcmd.2000.0353.
The erythrocyte Cl-/HCO3- anion exchanger (AE1, Band 3) and the enzyme carbonic anhydrase (CA) catalyze interconnected processes involved in bicarbonate metabolism. The high activity form of carbonic anhydrase, CAII binds to an acidic motif located within the carboxyl-terminal tail of anion exchangers via its basic amino-terminal region. CAII is thereby positioned at the cytosolic surface of the membrane, ideally placed to catalyze CO2 hydration and to channel bicarbonate to or from the anion exchanger. This association of a soluble enzyme and a membrane transporter may be an example of a metabolon, a weakly associated complex of sequential metabolic enzymes.
红细胞氯离子/碳酸氢根阴离子交换蛋白（AE1，带3蛋白）和碳酸酐酶（CA）催化参与碳酸氢盐代谢的相互关联的过程。碳酸酐酶的高活性形式CAII通过其碱性氨基末端区域与位于阴离子交换蛋白羧基末端尾部的酸性基序结合。因此，CAII定位于膜的胞质表面，处于理想位置以催化二氧化碳水合作用，并将碳酸氢根输送到阴离子交换蛋白或从阴离子交换蛋白输送出来。可溶性酶与膜转运蛋白的这种结合可能是代谢体的一个例子，代谢体是一种由顺序代谢酶组成的弱关联复合物。
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