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胚胎新皮层移植在体内对发育中的丘脑轴突产生的吸引力。

Attraction exerted in vivo by grafts of embryonic neocortex on developing thalamic axons.

作者信息

Frappé I, Gaillard A, Roger M

机构信息

Département des Neurosciences, CNRS, UMR 6558, Université de Poitiers, 86022 Poitiers Cedex, France.

出版信息

Exp Neurol. 2001 Jun;169(2):264-75. doi: 10.1006/exnr.2001.7669.

DOI:10.1006/exnr.2001.7669
PMID:11358441
Abstract

In a previous study we provided evidence that embryonic (E) day 16 frontal cortical cells grafted into the occipital cortex of newborn rats receive inputs from the ventrolateral (VL) and ventromedial (VM) thalamic nuclei which, normally, project to the frontal cortex (25). The present study was designed to examine further the conditions of development of the thalamic innervation of heterotopic neocortical grafts. We demonstrate that VL/VM axons do not provide transitory aberrant input to the occipital cortex either in intact newborn animals or in rats having received neonatal occipital lesion and subsequent graft of E16 occipital cells. These findings indicate, therefore, that the VL/VM projection to the graft does not result from the stabilization of an initial widespread cortical projection from these thalamic nuclei occurring either spontaneously or in response to the lesion and homotopic transplantation procedures. We also show that the VL/VM projection to frontal-to-occipital grafts develops within a few days posttransplantation and is maintained in adulthood. Finally, this study establishes that most VL/VM axons which enter the grafts are not collaterals of thalamofrontal axons. After having reached the cortex, they proceed caudally primarily within the infragranular layers. The findings of this and previous (25) in vivo studies for the first time provide evidence that developing thalamic axons have the capacity to respond to signals from grafts of E16 cortical cells and are capable of deviating their trajectory to establish contact with the grafts. Only those axons arising from thalamic nuclei appropriate for the cortical locus of origin of the grafted cells respond to the guidance signals. The mechanisms by which the thalamic axons find their way to the graft probably rely on cell-contact signaling and/or long-range attraction exerted by diffusible molecules.

摘要

在之前的一项研究中,我们提供了证据表明,移植到新生大鼠枕叶皮质的胚胎(E)第16天额叶皮质细胞接受来自腹外侧(VL)和腹内侧(VM)丘脑核的输入,而这些丘脑核通常投射到额叶皮质(25)。本研究旨在进一步研究异位新皮质移植丘脑神经支配的发育条件。我们证明,无论是在完整的新生动物中,还是在接受了新生儿枕叶损伤并随后移植E16枕叶细胞的大鼠中,VL/VM轴突都不会向枕叶皮质提供短暂的异常输入。因此,这些发现表明,VL/VM向移植组织的投射不是由于这些丘脑核最初广泛的皮质投射的稳定化,这种稳定化要么是自发发生的,要么是对损伤和同位移植程序的反应。我们还表明,VL/VM向额叶到枕叶移植组织的投射在移植后几天内发育,并在成年期维持。最后,本研究确定,进入移植组织的大多数VL/VM轴突不是丘脑额叶轴突的侧支。到达皮质后,它们主要在颗粒下层内尾向延伸。本研究及之前(25)的体内研究结果首次提供了证据,表明发育中的丘脑轴突有能力对来自E16皮质细胞移植组织的信号作出反应,并能够改变其轨迹以与移植组织建立联系。只有那些来自与移植细胞皮质起源部位相适应的丘脑核的轴突才会对引导信号作出反应。丘脑轴突找到通往移植组织路径的机制可能依赖于细胞接触信号传导和/或由可扩散分子施加的远程吸引。

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