Todorov S L
Strahlentherapie. 1975 Feb;149(2):197-204.
A quantitative analysis was carried out of structural chromosome aberrations in human perpheral lymphocytes exposed in vitro to 180 kV X-rays or 50 MeV protons. Statistical treatment of experimental findings by least-squares technique showed a regressional relationship between dose administered and yields of various chromosome aberration types. Fitting of the data to four mathematical models indicated, for both radiation types, that two-break aberrations, total number of aberrations and total of breaks are best fitted by the polinomial of second degree Y equals bD + CD-2, while one-break aberrations and number of aberrant cells are best fitted by the model Y equals a + bD. For all chromosome aberration types numerical values of the coefficients in these models are presented.
对体外暴露于180 kV X射线或50 MeV质子的人外周血淋巴细胞中的染色体结构畸变进行了定量分析。用最小二乘法对实验结果进行统计处理，结果表明所给予的剂量与各种染色体畸变类型的产额之间存在回归关系。将数据拟合到四个数学模型表明，对于这两种辐射类型，双断裂畸变、畸变总数和断裂总数最适合用二次多项式Y = bD + CD²拟合，而单断裂畸变和畸变细胞数最适合用模型Y = a + bD拟合。文中给出了这些模型中所有染色体畸变类型系数的数值。
