Andrlíková J, Wagner V, Pálek V
Strahlentherapie. 1975 Feb;149(2):212-8.
The levels of IgG, IgA and IgM were measured in the blood serum of uranium miners in a minin-district, where after a geological disturbance exposure to a high level of ionizing radiation took place. The mean exposure to 222-Rn daughters after first year was 7.35 WLM, after the second year 0.13 WLM only. Serum was sampled before miners started their occupation, for the second time after the first year and for the third time after the second year. The levels of IgG and IgM significantly decreased after one year of exposure, while the IgA changed only slightly. After the second year the levels of IgG and IgM significantly rose. IgG exceeded the initial levels: a regenerative hypercompensation took place. On the other hand IgA at the same time decreased. The IgG levels are only slightly correlated with radiation dose rate; for IgA and IgM the correlation is lacking. Individual Ig levels appear to be very variable. The reduction of IgG reached hypogammaglobulinemic levels in some miners after the first year and was followed by a propensity to infections of the respiratory tract. The significance of these observations is discussed from the immunological, radiological and radiohygienical point of view.
在一个矿区对铀矿工人血清中的IgG、IgA和IgM水平进行了测量，该矿区在一次地质扰动后发生了高水平电离辐射暴露。第一年之后对222 - Rn子体的平均暴露量为7.35工作水平月，而第二年之后仅为0.13工作水平月。在矿工开始工作前采集血清样本，第一年之后第二次采集，第二年之后第三次采集。暴露一年后，IgG和IgM水平显著下降，而IgA仅有轻微变化。第二年之后，IgG和IgM水平显著上升。IgG超过了初始水平：发生了再生性超补偿。另一方面，IgA同时下降。IgG水平与辐射剂量率仅有轻微关联；对于IgA和IgM则缺乏相关性。个体的免疫球蛋白水平似乎变化很大。第一年之后，一些矿工体内IgG的降低达到了低丙种球蛋白血症水平，随后出现了呼吸道感染倾向。从免疫学、放射学和放射卫生学角度对这些观察结果的意义进行了讨论。
