Wagner V, Skokanová V, Skokanová K, Wagnerová M, Heribanová A, Ríha M
Czech Med. 1984;7(2):65-77.
Total count of morbidity as well as prevalence of upper respiratory tract diseases (RTD) were followed in 210 miners working in shale mines with a low level of ionizing radiation regarding their smoking habits. After one and half year of observation were performed some tests of humoral immunity in the blood serum and saliva (immunoglobulins G, A, M and sIgA) as well as some tests of non-specific indices (alpha 2 macroglobulin -A 2M, transferrin -TRF, lysozyme -- LYS). The number of healthy non--smokers reached 41.3%, whereas the number of healthy smokers was only 26.5% (P less than 0.05). The greater was the number of diseases in single subjects, the greater was the difference between smokers and non-smokers (P less than 0.005). The difference between RTD morbidity of smokers and non-smokers was not significant in the subgroup of miners employed less than 10 years, but the length of employment it rose significantly (P less than 0.002) in disfavour of the smokers. The difference between smokers and non-smokers is emphasized by ageing. The mean levels of immunoglobulins (IgG, IgA, IgM) are significantly higher in healthy non-smokers in comparison with other miners; that is stressed also by distribution analysis. The distribution analysis. The distribution of A 2M values is also significantly different in the subgroup of healthy non-smokers compared with other miners. Highly significant differences were found between healthy non-smokers and other miners by discrimination analysis of coupled tests. The differences among the paired comperformed some tests of humoral immunity in the blood serum and saliva (immunoglobulins are apparently cooperative in the prevention of RTD. In contrast to that the level of A 2M are in reverse relationship to the levels of Ig; in the subgroup of healthy non-smokers low levels of A 2M are in connection with high levels of Ig of all three classes. The results are discussed from the point of view of the smoker's habits, the length of employment in mine's environment, the age of the miners and the supposed genetical factors.
对210名在电离辐射水平较低的页岩矿工作的矿工，根据其吸烟习惯追踪了上呼吸道疾病（RTD）的发病总数及患病率。经过一年半的观察，对血清和唾液进行了一些体液免疫测试（免疫球蛋白G、A、M和分泌型免疫球蛋白A）以及一些非特异性指标测试（α2巨球蛋白-A2M、转铁蛋白-TRF、溶菌酶-LYS）。健康非吸烟者的比例达到41.3%，而健康吸烟者的比例仅为26.5%（P<0.05）。个体疾病数量越多，吸烟者与非吸烟者之间的差异就越大（P<0.005）。在工作年限不足10年的矿工亚组中，吸烟者与非吸烟者的RTD发病率差异不显著，但随着工作年限增加，不利于吸烟者的差异显著上升（P<0.002）。年龄增长突出了吸烟者与非吸烟者之间的差异。健康非吸烟者的免疫球蛋白（IgG、IgA、IgM）平均水平明显高于其他矿工；分布分析也强调了这一点。A2M值的分布在健康非吸烟者亚组与其他矿工之间也有显著差异。通过联合测试的判别分析发现，健康非吸烟者与其他矿工之间存在高度显著差异。配对组合之间的差异表明，免疫球蛋白在预防RTD方面显然具有协同作用。与此相反，A2M水平与Ig水平呈反向关系；在健康非吸烟者亚组中，低水平的A2M与所有三类Ig的高水平相关。从吸烟者习惯、在矿山环境中的工作年限、矿工年龄以及假定的遗传因素等角度对结果进行了讨论。
