Seidel A
Strahlentherapie. 1975 Apr;149(4):442-9.
The retention of 241-Am during the first three months after injection as well as its microdistribution on the 2nd day were investigated in the rat and the Syrian hamster. Deposition, retention and microdistribution in the skeleton of both species are virtually identical; the same holds for kidneys, except for a higher initial deposition in the hamster. The microdistribution of 241-Am in kidneys and liver of both species is homogenous with a distinct accumulation in the cortical zone of the kidneys. A pronounced difference was observed with regard to the elimination of 241-Am from the liver: Most of the 241-Am is excreted by the rat liver with a half time of 7 days whereas this value is about 150 days for the Syrian hamster. The consequences of the species differences are discussed.
研究了大鼠和叙利亚仓鼠注射后前三个月内241-镅的滞留情况及其在第2天的微观分布。两种动物骨骼中的沉积、滞留和微观分布几乎相同；肾脏情况也一样，只是仓鼠肾脏中的初始沉积量更高。两种动物肾脏和肝脏中241-镅的微观分布是均匀的，在肾脏皮质区有明显积累。在241-镅从肝脏的消除方面观察到了显著差异：大鼠肝脏排泄了大部分241-镅，半衰期为7天，而叙利亚仓鼠的这个值约为150天。讨论了物种差异的后果。
