Zosimovskaia A I, Terslolj V V
Tsitologiia. 1975 Mar;17(3):266-71.
An increase in the incorporation of eH-uridine into RNA and in the cell membrane permeability for 3H-uridine in stationary culture cells after medium replenishment were found to be parallel. Increase in the RNA synthesis occurs practically in all cells stimulated to proliferate and is not accompanied by swelling nucleii, as demonstrated by measuring the projected areas of nucle on fixed cells. The rise in RNA synthesis as a response to proliferative stimulus is pronounced at every cell density but with increasing cell density fall in the magnitude of the response occurs.
发现培养基补充后,静止培养细胞中eH-尿苷掺入RNA的增加以及细胞膜对3H-尿苷的通透性增加是平行的。通过测量固定细胞中细胞核的投影面积表明,RNA合成的增加实际上发生在所有被刺激增殖的细胞中,并且不伴有细胞核肿胀。在每个细胞密度下,作为对增殖刺激的反应,RNA合成的增加都很明显,但随着细胞密度的增加,反应的幅度会下降。