Campbell J J, Qin S, Unutmaz D, Soler D, Murphy K E, Hodge M R, Wu L, Butcher E C
Joint Program in Transfusion Medicine, Children's Hospital, 300 Longwood Avenue, Room BD-401, Boston, MA 02115.
J Immunol. 2001 Jun 1;166(11):6477-82. doi: 10.4049/jimmunol.166.11.6477.
CD56, an adhesion molecule closely related to neural cell adhesion molecule, is an immunophenotypic marker for several unique populations of PBLS: Although CD56(+) cells derive from multiple lymphocyte lineages, they share a role in immunosurveillance and antitumor responses. We have studied the chemokine receptor expression patterns and functional migratory responses of three distinct CD56(+) populations from human peripheral blood. NK-T cells were found to differ greatly from NK cells, and CD16(+) NK cells from CD16(-) NK cells. CD16(+) NK cells were the predominant population responding to IL-8 and fractalkine, whereas NK-T cells were the predominant population responding to the CCR5 ligand macrophage-inflammatory protein-1beta. CD16(-) NK cells were the only CD56(+) population that uniformly expressed trafficking molecules necessary for homing into secondary lymphoid organs through high endothelial venule. These findings describe a diverse population of cells that may have trafficking patterns entirely different from each other, and from other lymphocyte types.
CD56是一种与神经细胞黏附分子密切相关的黏附分子，是几种独特的外周血淋巴细胞群的免疫表型标志物：尽管CD56(+)细胞源自多个淋巴细胞谱系，但它们在免疫监视和抗肿瘤反应中发挥共同作用。我们研究了来自人外周血的三种不同CD56(+)群体的趋化因子受体表达模式和功能性迁移反应。发现自然杀伤T细胞与自然杀伤细胞有很大差异，CD16(+)自然杀伤细胞与CD16(-)自然杀伤细胞也有很大差异。CD16(+)自然杀伤细胞是对白细胞介素-8和fractalkine作出反应的主要群体，而自然杀伤T细胞是对CCR5配体巨噬细胞炎性蛋白-1β作出反应的主要群体。CD16(-)自然杀伤细胞是唯一通过高内皮静脉归巢到二级淋巴器官所必需的转运分子均一表达的CD56(+)群体。这些发现描述了一群细胞，它们的转运模式可能彼此完全不同，也与其他淋巴细胞类型不同。
