Osaki S
Department of Chemistry, Faculty of Medicine, Nara Medical University, Kashihara, Nara 634-8521, Japan.
Anat Rec. 2001 Jun 1;263(2):161-6. doi: 10.1002/ar.1091.
Most people are interested in recovery of skin defects caused by burn, scald or trauma from the aesthetic and functional point of view. It will occupy an important role for successful skin graft for patients with such skin defects that the orientation of collagen fibers in the grafted skin matches to the fiber orientation in surrounding skin. There have been, to my best knowledge, no methods for determining the orientation of collagen fibers in the skin from the clinical point of view. Recently, the author has found a new method for directly determining the collagen-fiber orientation without cutting samples from a calf leather by analyzing the anisotropic shape of hair pore. Its principle is based on the quantitative evaluation of collagen-fiber orientation by approximating a hair pore to an ellipse. The results obtained by the new method using hair pores were supported by the microwave method, mechanical measurements and scanning electron microscopy. Such a method will be applicable for determining the orientational distribution of collagen fibers in skins of animals and humans and give a valuable probe for performing skin grafting based on the scientific data of hair pores.
从美学和功能角度来看，大多数人都对烧伤、烫伤或创伤所致皮肤缺损的修复感兴趣。对于此类皮肤缺损患者的皮肤移植成功而言，移植皮肤中胶原纤维的取向与周围皮肤中的纤维取向相匹配将起到重要作用。据我所知，从临床角度尚无确定皮肤中胶原纤维取向的方法。最近，作者发现了一种新方法，通过分析毛孔的各向异性形状，无需从小牛皮革上切割样本即可直接确定胶原纤维的取向。其原理基于将毛孔近似为椭圆来对胶原纤维取向进行定量评估。使用毛孔的新方法所获得的结果得到了微波法、力学测量和扫描电子显微镜的支持。这样一种方法将适用于确定动物和人类皮肤中胶原纤维的取向分布，并基于毛孔的科学数据为进行皮肤移植提供有价值的探测手段。
