Koonsaeng S, Verschraegen C, Freedman R, Bossens M, Kudelka A, Kavanagh J, Sittisomwong T, DeClercq E, Snoeck R
Gynecologic Oncology Unit, National Cancer Institute, Bangkok, Thailand.
J Med Virol. 2001 Jun;64(2):195-8. doi: 10.1002/jmv.1036.
Vulvar intraepithelial neoplasias are difficult to eradicate completely without extensive surgical intervention. Cidofovir, a deoxycytidine monophosphate analog, may have a therapeutic role in this disease. A 43-year-old woman with a 20-year history of genital warts presented with extensive vulvar intraepithelial neoplasia III, and refused surgical resection. Topical cidofovir 1% in Beeler base completely eradicated the lesion. Successive treatment applications, however, were necessary. Cidofovir is a promising topical antiviral compound for HPV induced vulvar intraepithelial neoplasia.
外阴上皮内瘤变若不进行广泛的手术干预，很难完全根除。西多福韦是一种单磷酸脱氧胞苷类似物，可能对这种疾病具有治疗作用。一名有20年尖锐湿疣病史的43岁女性，患有广泛的外阴上皮内瘤变III级，拒绝手术切除。在Beeler基质中使用1%的西多福韦局部用药完全消除了病变。然而，需要连续进行治疗。西多福韦是一种有前景的用于治疗人乳头瘤病毒引起的外阴上皮内瘤变的局部抗病毒化合物。
