Ray R S, Mehrotra S, Shankar U, Babu G S, Joshi P C, Hans R K
Photobiology Division, Industrial Toxicology Research Centre, Post Box No. 80, Mahatma Gandhi Marg, Lucknow 226001, U.P., India.
Drug Chem Toxicol. 2001 May;24(2):191-200. doi: 10.1081/dct-100102610.
Photosensitization reaction of drugs leading to the formation of reactive oxygen species (ROS) cause tissue injury causing damage to various cellular macromolecules. The aim of this study was to determine the superoxide anion (O2-) generation potential of commonly used antibiotics so that due precaution could be exercised to minimize their photosensitizing action and oxidative stress potential. The selected antibiotics were examined for their ability to produce (O2-) under sunlight and artificial UVA (320-400 nm) and UVB (290-320 nm). Lincomycin, cephalothin and erythromycin generated significant amount of O2- under various irradiation conditions. Superoxide dismutase (SOD), an enzymatic quencher of O2- inhibited O2- production in all drugs tested. The results suggest that due precaution are necessary to avoid ultraviolet radiation (UVR) after the intake of photoreactive drugs, especially in tropical and sub tropical countries.
药物的光敏反应导致活性氧（ROS）形成，进而引起组织损伤，对各种细胞大分子造成损害。本研究的目的是测定常用抗生素产生超氧阴离子（O2-）的潜力，以便采取适当预防措施，将其光敏作用和氧化应激潜力降至最低。对所选抗生素在阳光、人工紫外线A（320 - 400纳米）和紫外线B（290 - 320纳米）照射下产生（O2-）的能力进行了检测。林可霉素、头孢噻吩和红霉素在各种照射条件下均产生了大量的O2-。超氧化物歧化酶（SOD），一种O2-的酶促猝灭剂，抑制了所有受试药物中O2-的产生。结果表明，服用光反应性药物后，尤其是在热带和亚热带国家，有必要采取适当预防措施以避免紫外线辐射（UVR）。
