Oda M, Udaka F, Izumi Y, Sakaguchi K, Kaido M, Kameyama M
Department of Neurology and Internal Medicine, Sumitomo Hospital, 5-3-20 Nakanoshima, Kita-ku, Osaka 530-0005, Japan.
No To Shinkei. 2001 Apr;53(4):369-72.
The patient was 42-year-old woman who had exhibited elevated levels of serum creatine kinase(CK) and intermittent weakness of proximal muscles since her thirties. She had a history of palmoplantar pustulosis, Mondor's disease and recurrent miscarriages. Basedow's disease, which had been treated with antithyroid drugs since 37 years of age, recurred during the fourth pregnancy. After the pregnancy was terminated in the sixth week, weakness and grasp pain in the proximal muscles developed. The biopsy of biceps brachii muscle showed necrosis and reconstruction of muscle fibers with equivocal inflammatory cells, which was compatible with the findings for inflammatory myopathy such as polymyositis(PM). She was treated with prednisolone and the weakness and grasp pain in the proximal muscles were resolved. PM beginning during a woman's reproductive period is rare, and few studies have examined the association between PM and pregnancy. In this case, pregnancy and her past diseases were considered to be linked to an autoimmune abnormality that might have contributed to the inflammatory myopathy.
该患者为一名42岁女性，自三十多岁起血清肌酸激酶（CK）水平升高，近端肌肉间歇性无力。她有掌跖脓疱病、Mondor病和反复流产史。37岁起接受抗甲状腺药物治疗的Basedow病在第四次怀孕时复发。妊娠在第六周终止后，近端肌肉出现无力和抓握痛。肱二头肌活检显示肌纤维坏死和重建，伴有不明确的炎性细胞，这与炎性肌病如多发性肌炎（PM）的表现相符。她接受了泼尼松龙治疗，近端肌肉的无力和抓握痛得以缓解。女性生殖期开始的PM很少见，很少有研究探讨PM与妊娠之间的关联。在本病例中，妊娠和她过去的疾病被认为与自身免疫异常有关，这可能导致了炎性肌病。
