Sonntag H, Hellberg K, Schenk H D, Donath U, Regensburger D, Kettler D, Duchanova H, Larsen R
Acta Anaesthesiol Scand. 1975;19(1):69-78. doi: 10.1111/j.1399-6576.1975.tb05224.x.
The influence of thiopental (Trapanal) on coronary blood flow (MPF), myocardial oxygen consumption (MVO2), and general haemodynamics was investigated in seven patients without heart disease. Besides measurement of MBF, the amount of substrates (glucose, lactate, pyruvate and free fatty acids (FFA) was also determined in arterial and coronary sinus blood samples. Thiopental was given intravenously in a mean dose of 4 mg/kg b,w, MBF was measured by means of the argon method. After injection of thiopental, all seven patients showed a significant increase of MBF and MVO2, a fact which can essentially be explained by the increase of heart rate. The effects of thiopental on arterial concentrations, arterior-coronary substrate differences, myocardial uptake, and O2-extraction ratio of the different substrates are discussed.
在7名无心脏病的患者中研究了硫喷妥钠（曲砜那）对冠状动脉血流量（MPF）、心肌耗氧量（MVO2）和一般血流动力学的影响。除了测量MBF外，还测定了动脉血和冠状窦血样本中底物（葡萄糖、乳酸、丙酮酸和游离脂肪酸（FFA））的含量。硫喷妥钠以平均剂量4mg/kg体重静脉给药，MBF采用氩气法测量。注射硫喷妥钠后，所有7名患者的MBF和MVO2均显著增加，这一事实基本上可以通过心率增加来解释。讨论了硫喷妥钠对不同底物的动脉浓度、动脉-冠状动脉底物差异、心肌摄取和氧摄取率的影响。
