Lutken T, Baker B S
Mutat Res. 1979 Jul;61(2):221-7. doi: 10.1016/0027-5107(79)90129-5.
Recombination-defective female meiotic mutants representing 7 loci in Drosophila melanogaster have been examined for effects on gonial recombination in males. These loci were chosen for study because they represent a broad range of the known types of defects in processes necessary for meiotic recombination and somatic chromosome stability. Alleles at 6 of the loci studied did not increase the frequency of gonial recombination in males, whereas a mutant at one locus was associated with an increase (about 10-fold) in gonial recombination. These results suggest that the defects in chromosomal metabolism caused by these recombination, and in some cases repair, defective mutants are distinct from those of the male-recombination promoting elements (Mr) recently isolated from many natural populations. Analysis of the spontaneous events detected in this study showed that a third to a half of the events detected are actually of mutational rather than recombinational origin.
对代表黑腹果蝇7个基因座的重组缺陷型雌性减数分裂突变体进行了检测，以研究其对雄性生殖细胞重组的影响。选择这些基因座进行研究是因为它们代表了减数分裂重组和体细胞染色体稳定性所需过程中已知的广泛类型的缺陷。所研究的7个基因座中有6个的等位基因并未增加雄性生殖细胞重组的频率，而其中一个基因座的突变体与生殖细胞重组增加（约10倍）有关。这些结果表明，由这些重组缺陷型（在某些情况下是修复缺陷型）突变体引起的染色体代谢缺陷与最近从许多自然种群中分离出的促进雄性重组元件（Mr）的缺陷不同。对本研究中检测到的自发事件的分析表明，检测到的事件中有三分之一到一半实际上是突变起源而非重组起源。
