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黑腹果蝇减数分裂重组和体细胞DNA代谢的遗传控制

Genetic controls of meiotic recombination and somatic DNA metabolism in Drosophila melanogaster.

作者信息

Baker B S, Boyd J B, Carpenter A T, Green M M, Nguyen T D, Ripoll P, Smith P D

出版信息

Proc Natl Acad Sci U S A. 1976 Nov;73(11):4140-4. doi: 10.1073/pnas.73.11.4140.

Abstract

Recombination-defective meiotic mutants and mutagen-sensitive mutants of D. melanogaster have been examined for their effects on meiotic chromosome behavior, sensitivity to killing by mutagens, somatic chromosome integrity, and DNA repair processes. Several loci have been identified that specify functions that are necessary for both meiotic recombination and DNA repair processes, whereas mutants at combination and DNA repair processes, whereas mutants at other loci appear to be defective in only one pathway of DNA processing.

摘要

已经对黑腹果蝇的重组缺陷型减数分裂突变体和诱变剂敏感突变体进行了研究,以考察它们对减数分裂染色体行为、对诱变剂杀伤的敏感性、体细胞染色体完整性以及DNA修复过程的影响。已经鉴定出几个位点,这些位点所指定的功能对于减数分裂重组和DNA修复过程都是必需的,而其他位点的突变体似乎仅在DNA处理的一条途径中存在缺陷,而在减数分裂重组和DNA修复过程中存在缺陷。

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