Study of the variation of urinary protein patterns referring to the histopathological changes in renal diseases.

Protein constituents of the concentrated urine prepared from 131 patients with various renal diseases were analysed by the use of electrophoretic and immunochemical methods, referring to histopathological findings of the kidney obtained from biopsy or autopsy. Excretion of macromolecular serum proteins in the urine would be promoted not only by the lesion in glomerular filtration but also by the damage in tubular structure due to severe inflammatory change. From the evaluation of levels of immunoglobulins and various autoantibodies in the blood and urine, there could be found that their increase in the urine was mostly associated with chronic persistent inflammatory reactions followed by destructive changes in parenchymal tissue of the kidney. Investigation of the features of urinary protein and activities of autoantibodies in the urine is likely to be advantageous for the differentiation or renal disease and the decision of condition in individual patient. However, it must be noted that variation of the urinary patterns is caused by more complicated pathologic changes in whole kidney rather than the disturbance of glomerular filtrating mechanism.