Fowler R C, Tsuang M T, Cadoret R J, Monnelly E
Acta Psychiatr Scand. 1975 Mar;51(3):153-60. doi: 10.1111/j.1600-0447.1975.tb00001.x.
The present study was designed to test the hypothesis of "schizophrenic spectrum" disorders. The families of 60 process schizophrenics were systematically interviewed with structured interview forms, and evaluated for psychiatric illness according to strict diagnostic criteria. The interviewed persons were then separated into two groups for comparative analysis according to a positive (FH+) or negative (FH-) family history for schizophrenia. The frequencies of affective disorder and all non-psychotic conditions did not differ to a convincingly significant degree between the two groups. Our data thus fail to support the "schizophrenic spectrum" hypothesis in which neurosis and sociopathy occur as a consequence of a genetic loading for schizophrenia.?
本研究旨在检验“精神分裂症谱系”障碍的假说。采用结构化访谈表格对60例过程性精神分裂症患者的家属进行了系统访谈，并根据严格的诊断标准对其精神疾病进行评估。然后，根据精神分裂症家族史阳性（FH+）或阴性（FH-）将受访人员分为两组进行对比分析。两组之间情感障碍和所有非精神病性状况的发生率并无显著差异。因此，我们的数据未能支持“精神分裂症谱系”假说，即神经症和反社会人格障碍是精神分裂症遗传负荷的结果。
