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人体前臂肌肉和皮下组织中外源性甘油三酯的清除

Removal of exogenous triglycerides in human forearm muscle and subcutaneous tissue.

作者信息

Kaijser L, Rössner S

出版信息

Acta Med Scand. 1975 Apr;197(4):289-94. doi: 10.1111/j.0954-6820.1975.tb04919.x.

DOI:10.1111/j.0954-6820.1975.tb04919.x
PMID:1136856
Abstract

The removal of exogenous triglyceride (TG) in forearm muscle and subcutaneous tissue of 7 healthy male volunteers has been studied by nephelometric determinations of arterial-deep venous (a-dv) and arterial-superficial venous (a-sv) differences in concentration of fat particles. Exogenous TG was administered as a constant i.v. infusion of Intralipid over a period of 30 min at reat and another 15 min during forearm work. At rest a significant positive a-dv difference in fat particle concentration of 121 plus pr minus 21 mumol TG/l (mean plus or minus S.E.M.) was found, which correspondens to a fractional extraction of 1093 plus or minus 2.0%. Also the a-sv difference was significant, 81 plus or minus 14 mumol TG/l, 5.7 plus or minus 0.8% of the arterial concentration. During exercise no further significant removal was found. Thus both skeletal muscle and subcutaneous tissue seem to be able to remove exogenous TG in substantial amounts under resting conditions. In the exercising muscle, however, the direct removal of exogenous TG does not seem to be of significant importance.

摘要

通过比浊法测定7名健康男性志愿者前臂肌肉和皮下组织中动脉-深静脉(a-dv)以及动脉-浅静脉(a-sv)之间脂肪颗粒浓度的差异,研究了外源性甘油三酯(TG)的清除情况。外源性TG通过静脉持续输注英脱利匹特的方式给药,静息状态下输注30分钟,前臂运动期间再输注15分钟。静息状态下,脂肪颗粒浓度的a-dv差异显著为正值,为121±21μmol TG/l(平均值±标准误),相当于1093±2.0%的分数提取率。a-sv差异也很显著,为81±14μmol TG/l,占动脉浓度的5.7±0.8%。运动期间未发现进一步的显著清除。因此,在静息条件下,骨骼肌和皮下组织似乎都能够大量清除外源性TG。然而,在运动的肌肉中,外源性TG的直接清除似乎并不重要。

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