Wolf B W, Wolever T M, Bolognesi C, Zinker B A, Garleb K A, Firkins J L
Ross Products Division, Abbott Laboratories, Columbus, Ohio 43215, USA.
J Agric Food Chem. 2001 May;49(5):2674-8. doi: 10.1021/jf0015017.
To evaluate the glycemic response to a food starch esterified by 1-octenyl succinic anhydride (OSA), 30 healthy nondiabetic adult subjects were studied in a double-blind crossover design. After an overnight fast, subjects consumed a product containing either 25 g of glucose or 25 g of OSA-substituted starch. Finger-prick capillary blood was obtained at baseline and 15, 30, 45, 60, 90, and 120 min postprandial for glucose measurement. After OSA treatment, the rise in blood glucose was reduced (P < 0.05) at 15 and 30 min and tended (P < 0.08) to be lower at 45 min. Mean peak rise in glucose was reduced 19% (P < 0.01) by OSA (3.30 +/- 0.19 versus 2.66 +/- 0.16 mmol/L) compared to glucose, but time to peak did not differ between treatments. Net incremental area under the curve was also lower (P < 0.05) on OSA compared to glucose. Minimal effects on gastrointestinal symptoms (intensity and frequency of nausea, cramping, distention, and flatulence) were noted for both products, with no clinically significant difference between products. In conclusion, starch substitution with OSA attenuated the postprandial glycemic excursion compared to an equivalent glucose challenge and was well tolerated by fasting healthy adult subjects.
为评估1-辛烯基琥珀酸酐（OSA）酯化的食品淀粉的血糖反应，采用双盲交叉设计对30名健康非糖尿病成年受试者进行了研究。经过一夜禁食后，受试者食用了含有25克葡萄糖或25克OSA替代淀粉的产品。在基线以及餐后15、30、45、60、90和120分钟采集指尖毛细血管血用于测量血糖。经OSA处理后，血糖在15分钟和30分钟时升高幅度降低（P<0.05），在45分钟时升高幅度有降低趋势（P<0.08）。与葡萄糖相比，OSA使葡萄糖的平均峰值升高降低了19%（P<0.01）（分别为3.30±0.19 mmol/L和2.66±0.16 mmol/L）但两种处理之间达到峰值的时间没有差异。与葡萄糖相比，OSA的曲线下净增量面积也较低（P<0.05）。两种产品对胃肠道症状（恶心、绞痛、腹胀和肠胃胀气的强度和频率）的影响均最小，产品之间无临床显著差异。总之，与等量葡萄糖激发相比，用OSA替代淀粉可减轻餐后血糖波动，并且禁食的健康成年受试者对其耐受性良好。
