Dottorini M E
U.O. Medicina Nucleare Ospedale di Circolo Piazzale Solaro 3, 21052 Busto Arsizio, VA, Italy.
Rays. 2000 Apr-Jun;25(2):245-55.
Differentiated thyroid carcinoma is rare in childhood and shows different characteristics as compared to thyroid carcinoma in adults. The male/female ratio is different, it has a higher aggressiveness, locoregional and distant metastases are frequent, response to surgery and 131I radioiodine therapy is optimal. A better knowledge of these characteristics has resulted in the understanding of some relevant aspects of the pathogenesis and natural history of the disease, the suitability of the therapeutic approach and the incidence of adverse side-effects. The increased incidence of differentiated thyroid carcinoma in childhood following the Chernobyl nuclear accident of April 1986 renewed the interest of the scientific community and the public opinion and allowed an in-depth study of some important aspects correlated with the carcinogenic effect of ionizing radiation.
分化型甲状腺癌在儿童期较为罕见，与成人甲状腺癌相比具有不同的特征。男女比例不同，侵袭性更强，局部和远处转移常见，对手术和131I放射性碘治疗反应最佳。对这些特征的深入了解有助于认识该疾病发病机制和自然史的一些相关方面、治疗方法的适用性以及不良反应的发生率。1986年4月切尔诺贝利核事故后儿童分化型甲状腺癌发病率的增加重新引起了科学界和公众的关注，并使得对与电离辐射致癌作用相关的一些重要方面进行深入研究成为可能。
