Orabi K Y, Galal A M, Ibrahim A R, El-Feraly F S, McPhail A T
Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Z Naturforsch C J Biosci. 2001 Mar-Apr;56(3-4):216-22. doi: 10.1515/znc-2001-3-408.
Microbial bioconversion studies conducted on the diterpene psiadin have revealed that it was metabolized by Aspergillus niger (NRRL 2295) to give 2alpha-hydroxydeoxopsiadin, Cunninghamella blakesleeana (ATCC 8688a) to give 11beta-hydroxypsiadin, and Cylindrocephalum aureum (ATCC 12720), Gongronella butleri (ATCC 22822), Kloeckera africana (ATCC 20111), and Kluyveromyces marxianus var. lactis (ATCC 2628) to yield 7alpha-hydroxypsiadin. Their structures have been established on the basis of spectral data. The structure and relative stereochemistry of 7alpha-hydroxypsiadin was confirmed by single-crystal X-ray analysis.
对二萜类化合物psiadin进行的微生物生物转化研究表明，黑曲霉（NRRL 2295）将其代谢生成2α-羟基脱氧psiadin，布氏被孢霉（ATCC 8688a）将其代谢生成11β-羟基psiadin，而金黄柱顶孢霉（ATCC 12720）、布氏共头霉（ATCC 22822）、非洲克鲁维酵母（ATCC 20111）和马克斯克鲁维酵母乳酸变种（ATCC 2628）将其代谢生成7α-羟基psiadin。它们的结构已根据光谱数据确定。7α-羟基psiadin的结构和相对立体化学通过单晶X射线分析得到证实。
