Wilbur B G, Gomez F C, Tompkins R K
Arch Surg. 1975 Jul;110(7):792-6. doi: 10.1001/archsurg.1975.01360130024005.
Three groups of four dogs each underwent proximal gastric vagotomy, truncal vagotomy, or truncal vagotomy with pyloroplasty. Two dogs had sham operations. Gallbladder bile was aspirated and measured. Aliquots were cultured and assayed for cholesterol, phospholipid, and bile salts initially and at subsequent laparotomies. Both truncal vagotomy groups showed marked increases in aspirate volume at subsequent laparotomies. The sham and proximal gastric vagotomy groups showed a small initial decrease in mean aspirate volume without further significant changes. When the bile assay data were plotted on triangular coordinates, all point for all groups remained well within the area of cholesterol solubility. Nevertheless, two dogs in each truncal vagotomy group were found to have gallstones. No stones were found in the sham and proximal gastric vagotomy groups. Proximal gastric vagotomy appears to preserve fasting gallbladder bile volume and does not alter bile composition in the dog.
三组实验，每组四只狗，分别接受了近端胃迷走神经切断术、迷走神经干切断术或迷走神经干切断术加幽门成形术。两只狗接受了假手术。抽取并测量胆囊胆汁。最初以及随后的剖腹手术时，取部分胆汁进行培养，并检测胆固醇、磷脂和胆汁盐。两个迷走神经干切断术组在随后的剖腹手术时胆汁抽吸量均显著增加。假手术组和近端胃迷走神经切断术组最初平均胆汁抽吸量略有下降，之后无进一步显著变化。当将胆汁检测数据绘制在三角坐标图上时，所有组的所有点均仍处于胆固醇溶解度区域内。然而，每个迷走神经干切断术组均发现两只狗患有胆结石。假手术组和近端胃迷走神经切断术组未发现结石。近端胃迷走神经切断术似乎能保持空腹时胆囊胆汁量，且不改变狗的胆汁成分。
