McMaster P, Medd R K, McLeish R N
Eur Surg Res. 1979;11(3):191-204. doi: 10.1159/000128067.
An increased incidence of gallstones has been reported following truncal vagotomy and gastric drainage but never conclusively proven. In the Rhesus monkey, bile composition and flow is similar to man. A model of biliary drainage was established which permits continuous monitoring of bile kinetics. Following truncal vagotomy and pyloroplasty, a significant fall in the bile acid concentration was observed, accompanied by a rise in cholesterol concentration. This resulted in an overall rise in cholesterol saturation. Similar changes in hepatic bile composition were, however, also seen following pyloroplasty alone, and suggests that the vagotomy itself may not be the important factor in producing bile changes.
据报道，迷走神经切断术和胃引流术后胆结石发病率有所增加，但从未得到确凿证实。恒河猴的胆汁成分和流量与人类相似。建立了一种胆汁引流模型，可对胆汁动力学进行连续监测。在进行迷走神经切断术和幽门成形术后，观察到胆汁酸浓度显著下降，同时胆固醇浓度升高。这导致胆固醇饱和度总体上升。然而，仅进行幽门成形术后，肝胆汁成分也出现了类似变化，这表明迷走神经切断术本身可能不是导致胆汁变化的重要因素。
