Vuong D, Capon R J, Lacey E, Gill J H, Heiland K, Friedel T
School of Chemistry, University of Melbourne, Parkville, Victoria, 3010, Australia.
J Nat Prod. 2001 May;64(5):640-2. doi: 10.1021/np000474b.
A southern Australian marine sponge, Trachycladus laevispirulifer, has yielded a potent new nematocide with antifungal activity which has been identified as onnamide F (1). The structure for 1 was assigned by detailed spectroscopic analysis and chemical conversion to the methyl ester 2. Onnamide F contains a common structural motif previously described in a number of natural products exhibiting interesting pharmacological activities, including the insect chemical defense agent pederin (3), and the sponge metabolites the onnamides, mycalamides, and theopederins.
澳大利亚南部的一种海洋海绵，光滑螺旋海绵（Trachycladus laevispirulifer），产生了一种具有抗真菌活性的强效新型杀线虫剂，已被鉴定为奥纳米德F（1）。通过详细的光谱分析和化学转化为甲酯2确定了1的结构。奥纳米德F含有一种常见的结构基序，此前在许多具有有趣药理活性的天然产物中都有描述，包括昆虫化学防御剂佩德林（3），以及海绵代谢产物奥纳米德、麦卡拉米德和西奥佩德林。
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