Capon Robert J, Ford Joanne, Lacey Ernest, Gill Jennifer H, Heiland Kirstin, Friedel Thomas
School of Chemistry, University of Melbourne, Parkville, Victoria 3010, Australia.
J Nat Prod. 2002 Mar;65(3):358-63. doi: 10.1021/np010329d.
Bioassay-directed fractionation of two southern Australian sponges, Phoriospongia sp. and Callyspongia bilamellata, yielded two new nematocidal depsipeptides, identified as phoriospongins A (1) and B (2). The structures of the phoriospongins were determined by detailed spectroscopic analysis and comparison with the previously reported sponge depsipeptide cyclolithistide A (3), as well as ESIMS and HPLC analysis of acid hydrolysates. It is noteworthy that the unique and yet structurally related metabolites 1-3 are found in sponges spanning three taxonomic orders, Poescilosclerida, Haplosclerida, and Lithistida.
对两种澳大利亚南部海绵——Phoriospongia sp.和双片层海绵（Callyspongia bilamellata）进行生物测定导向的分级分离，得到了两种新的杀线虫缩肽，分别鉴定为phoriospongins A（1）和B（2）。通过详细的光谱分析，并与先前报道的海绵缩肽环石海绵素A（3）进行比较，以及对酸水解产物进行电喷雾离子化质谱（ESIMS）和高效液相色谱（HPLC）分析，确定了phoriospongins的结构。值得注意的是，在跨越三个分类目（简骨海绵目、单轴海绵目和硬海绵目）的海绵中发现了独特但结构相关的代谢产物1 - 3。
