Galasko D
Department of Neurosciences, University of California, San Diego, California 92161, USA.
Clin Geriatr Med. 2001 May;17(2):393-410. doi: 10.1016/s0749-0690(05)70075-6.
An explosion of scientific and clinical knowledge about Alzheimer's disease now provides a basis for selecting targets for treatment aimed at slowing progression of dementia or delaying the onset of or preventing Alzheimer's disease. The rationale that underlies several promising approaches to treatment are reviewed. Novel forms of treatment are most effective when combined with sensitive clinical methods to diagnose Alzheimer's disease as early as possible and to track its progression over time. Therefore, this article highlights findings concerning biological markers for Alzheimer's disease and the mild cognitive impairment syndrome and attempts to define a prodromal stage of Alzheimer's disease.
目前，关于阿尔茨海默病的科学和临床知识呈爆发式增长，这为选择旨在减缓痴呆进展或延迟阿尔茨海默病发病或预防其发生的治疗靶点提供了依据。本文综述了几种有前景的治疗方法的基本原理。新型治疗方法与敏感的临床方法相结合时最为有效，这些临床方法能够尽早诊断阿尔茨海默病并随时间追踪其进展。因此，本文重点介绍了有关阿尔茨海默病和轻度认知障碍综合征生物标志物的研究结果，并试图定义阿尔茨海默病的前驱阶段。
