Villar J
Research Institute, Hospital N. S. de Candelaria, Carretera del Rosario, s/n, 38010 Santa Cruz de Tenerife, Canary Islands, Spain.
Minerva Anestesiol. 2001 Apr;67(4):193-7.
As a result of the progress in molecular biology and genetics over the last 20 years, now it seems clear that the pathogenesis of most diseases is influenced by the genotype, the environment and the nature of the process which leads to the injury. Current evidence also suggests that genetic factors are associated with susceptibility to pulmonary diseases. The author reviews some of these complex interactions suggesting that even the inflammatory response during lung injury can be influenced by genetic polymorphisms.
由于过去20年分子生物学和遗传学的进展，现在似乎很清楚，大多数疾病的发病机制受到基因型、环境以及导致损伤的过程的性质的影响。目前的证据还表明，遗传因素与肺部疾病的易感性有关。作者回顾了其中一些复杂的相互作用，表明即使是肺损伤期间的炎症反应也可能受到基因多态性的影响。
