Blanker M H, Groeneveld F P, Bohnen A M, Bernsen R M, Prins A, Thomas S, Ruud Bosch J L
Department of General Practice, Erasmus University Rotterdam, Rotterdam, The Netherlands.
Urology. 2001 Jun;57(6):1093-8 discussion 1098-9. doi: 10.1016/s0090-4295(01)00988-8.
To determine the normal values of voided volumes and explore the relation between bladder capacity and lower urinary tract symptoms (LUTS) in elderly men.
Data were collected from 1688 men 50 to 78 years old recruited from the population of Krimpen aan den IJssel, The Netherlands. Measurements included self-administered questionnaires (including the International Prostate Symptom Score), a 3-day frequency volume chart, transrectal ultrasonography of the prostate, uroflowmetry, and postvoid residual volume determination.
The 24-hour voided volumes were independent of age (median 1506 mL; 25th to 75th percentiles 1160 to 1950). The average volume per void and functional bladder capacity (FBC, defined as the largest single voided volume) declined with advancing age. Moreover, FBC was lower in men with a reduced maximum flow rate (less than 15 mL/s) and independent of the postvoid residual volume. Multivariate analyses showed no significant effect of prostate enlargement on the FBC. FBC was strongly related to LUTS: a low FBC coincided with higher International Prostate Symptom Scores. Multivariate logistic regression analyses revealed that the presence of moderate to severe symptoms (International Prostate Symptom Score greater than 7) was independent of prostate volume, but dependent on age, a reduced flow rate, postvoid residual volume, and FBC.
Prospective studies are needed to establish the causal relation between FBC and LUTS. Frequency volume charts are a valid, easy-to-use, noninvasive method to determine FBC as an aspect of urinary tract (dys)function in the evaluation of men with LUTS and to determine treatment options for LUTS.
确定排尿量的正常值，并探讨老年男性膀胱容量与下尿路症状（LUTS）之间的关系。
收集了从荷兰克林彭安登艾瑟尔人群中招募的1688名50至78岁男性的数据。测量包括自行填写的问卷（包括国际前列腺症状评分）、3天的排尿频率-尿量图表、经直肠前列腺超声检查、尿流率测定和排尿后残余尿量测定。
24小时排尿量与年龄无关（中位数为1506 mL；第25至75百分位数为1160至1950）。每次排尿的平均尿量和功能性膀胱容量（FBC，定义为最大单次排尿量）随年龄增长而下降。此外，最大尿流率降低（小于15 mL/s）的男性FBC较低，且与排尿后残余尿量无关。多变量分析显示前列腺增大对FBC无显著影响。FBC与LUTS密切相关：FBC较低与较高的国际前列腺症状评分同时出现。多变量逻辑回归分析显示，中度至重度症状（国际前列腺症状评分大于7）的存在与前列腺体积无关，但与年龄、尿流率降低、排尿后残余尿量和FBC有关。
需要进行前瞻性研究以确定FBC与LUTS之间的因果关系。排尿频率-尿量图表是一种有效、易用的非侵入性方法，可用于在评估LUTS男性时确定FBC作为尿路（功能）障碍的一个方面，并确定LUTS的治疗方案。
