Preston T J, Abadi A, Wilson L, Singh G
Department of Pathology and Molecular Medicine, McMaster University, 699 Concession St., Hamilton, Ontario, Canada L8V 5C2.
Adv Drug Deliv Rev. 2001 Jul 2;49(1-2):45-61. doi: 10.1016/s0169-409x(01)00127-2.
Mitochondria make an integral contribution to the regulation of several aspects of cell biology such as energy production, molecular metabolism, redox status, calcium signalling and programmed cell death. In accordance with an endosymbiotic origin, mitochondria rely upon the nucleus for synthesis and function. In addition, these organelles can respond to intra- and extracellular cues independently, and there exists a highly coordinated "cross talk" between mitochondrial and nuclear signals that can greatly influence cell behaviour. This review focuses upon the putative roles of altered mitochondrial physiology in the process of cellular transformation. Discussed are: mitochondria as targets of drug-induced cytotoxicity or cancer promotion, as regulators of apoptosis, as sources of cell signalling through reactive oxygen species, and mitochondrial control of specific nuclear responses.
线粒体对细胞生物学的多个方面的调节起着不可或缺的作用，如能量产生、分子代谢、氧化还原状态、钙信号传导和程序性细胞死亡。根据内共生起源理论，线粒体的合成和功能依赖于细胞核。此外，这些细胞器能够独立地对细胞内和细胞外的信号作出反应，并且线粒体信号与核信号之间存在高度协调的“串扰”，这会极大地影响细胞行为。本综述聚焦于线粒体生理改变在细胞转化过程中的假定作用。讨论的内容包括：线粒体作为药物诱导的细胞毒性或癌症促进作用的靶点、作为细胞凋亡的调节因子、作为通过活性氧进行细胞信号传导的来源以及线粒体对特定核反应的控制。
